The rate of mortality from breast cancer has fallen by one third over the last 30 years. This is due to improvements in early detection, the refinement of treatment concepts and the development of new ones. Nowadays, an important issue for breast cancer experts is also how they can improve the quality of life of their patients. This is one of the main focuses of the Comprehensive Cancer Center (CCC) of MedUni Vienna and Vienna General Hospital – as is the issue of "overtreatment". Together with the development of new treatment guidelines, these two topics are central themes at the 15th St. Gallen Breast Cancer Conference and the 3rd Vienna Breast Surgery Day, which will take place in Vienna from 14 to 18 March 2017.

Figure 1: Architecture of skeletal muscle formed by regular arrays of myosin and actin filaments.

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka University reveal unexpectedly large conformational changes in the myosin molecule during the pull. These findings, which can be seen in Nature Communications, provide new insights into how myosin generates force and a paradigm for the construction of nanomachines. To biophysicists like Keiichi Namba, professor at Osaka University, the ability of tiny molecules to generate large amounts of force seen in muscle make myosin an engineering marvel. "Myosin and actin are nanomachines that convert the chemical energy of ATP hydrolysis into mechanical work" he says.

Eastern brook trout

Aquaculture, or fish farming, is one of the fastest growing sectors of agriculture in the world today. However, farmers in the United States who wish to capitalize on this momentum face regulatory hurdles when dealing with fish waste. But new research shows that a simple, organic system can clean aquaculture wastewater effectively and inexpensively. Researchers built bioreactors—long containers filled with wood chips—to treat wastewater from a fully operational recirculating aquaculture system in West Virginia. The idea is simple: water from the fish tank enters the bioreactor at one end, flows through the wood chips, and exits through a pipe at the other end. Along the way, solids settle out and bacteria housed in the wood chips remove nitrogen, a regulated pollutant.

Researchers from Turku Centre for Biotechnology have observed that a protein called SHANK prevents the spread of breast cancer cells to the surrounding tissue. The SHANK protein has been previously studied only in the central nervous system, and it is known that its absence or gene mutations are related to autism. The research was conducted at Turku Centre for Biotechnology. The novel discovery impinges upon the protein called SHANK which has been intensively studied in several processes in central nervous system and gene mutations in SHANK are linked to autism. The same factors can regulate cell shape and adhesion in very different cell types. Our results revealed that gene mutations in SHANK, found in autistic patients, impair SHANKs ability to prevent the adherence of both neurons and breast cancer cells. This once again demonstrates the power of basic research in facilitating our understanding of several human diseases, rejoices Academy professor Johanna Ivaska.

People with social anxiety avoid situations in which they are exposed to judgment by others. Those affected also lead a withdrawn life and maintain contact above all on the Internet. Around one in ten people is affected by this anxiety disorder over the course of their life. Researchers at the University of Bonn have now found evidence for a gene that is believed to be linked to the illness. It encodes a serotonin transporter in the brain. Interestingly, this messenger suppresses feelings of anxiety and depressiveness. The scientists want to investigate this cause more precisely and are thus looking for more study participants. The results will be published in the journal “Psychiatric Genetics”.

Do anogenital lesions of HIV-positive men that clinically appear as benign warts contain areas of dysplasia, and if so, what are the virological characteristics of those lesions? Findings  In this case series, a high proportion of anogenital warts contained areas of high-grade and low-grade dysplasia or even invasive cancer. Some of these lesions contained only low-risk-HPV types. Dysplasia was absent in all lesions of immunocompetent control patients.

Human papillomavirus (HPV)-induced anogenital lesions are very frequent in men who have sex with men (MSM) who are HIV-positive (HIV+). Anogenital warts (AGWs) are considered benign lesions caused by low-risk HPV-types, whereas anogenital dysplasias are potential cancer precursors associated with high-risk HPV-types. Both types of lesions can usually be distinguished clinically.

A marine science iBook entitled “Harmful Algal Blooms” has been developed as part of NUI Galway’s contribution to an EU-funded European research project Sea Change. The project aims to raise European citizens’ awareness of the ocean’s influence on us and our influence on the ocean, or “Ocean Literacy”. The iBook will be launched by Professor Colin Brown, Director of the Ryan Institute for Environmental, Marine and Energy Research on Monday 13 March at the National University of Ireland, Galway.

13 March 2017 — 18 March 2017

Location: Trieste - Gorizia, Italy

Venue: Various

Ticket prices: Free

Artificial intelligence, language, time perception, nutrition, vaccines: these are some of the themes that will be covered from the 13th to 18th of March in Trieste - and for the first time also in Gorizia - for Brain Awareness Week. The local initiative is organised by the Interdisciplinary Laboratory of SISSA in Trieste and the BRAIN Centre of the Department of Life Sciences of the University of Trieste, in collaboration with the Science Centre Immaginario Scientifico and the Municipality of Trieste. Performances, panel discussions, educational laboratories, workshops, scientific cafés, conferences, visits to laboratories: a broad range of appointments for everyone and for all ages.

The structure of the FAS enzyme (left), and foreign enzymes embedded into the chambers of FAS (right).

There have been many attempts to modify this stubborn little enzyme, but none have succeeded. Until now. With new findings from Chalmers University of Technology, the fatty acid synthase (FAS) enzyme has started to produce sustainable chemicals for biofuels. The results were recently published in the journal Nature Chemical Biology. We are in great need of sustainable and clean alternatives to oil-derived products. One of the choices at hand is to produce chemicals and biofuels from sustainable biomass. To do this, a research team at Chalmers University of Technology is hard at work trying to design yeast cell factories that can actually produce the chemicals we need in a sustainable way. The group has now had a major breakthrough, having developed a novel method of modifying the fatty acid synthase (FAS) enzyme so that it can create new products.

Gaseous neurotransmitters play an important role in the short-term orientation memory of Drosophila / Scientist decode biochemical processes . Insects have a spatial orientation memory that helps them remember the location of their destination if they are briefly deflected from their route. Researchers at Johannes Gutenberg University Mainz (JGU) have examined how this working memory functions on the biochemical level in the case of Drosophila melanogaster. They have identified two gaseous messenger substances that play an important role in signal transmission in the nerve cells, i.e., nitric oxide and hydrogen sulfide. The short-term working memory is stored with the help of the messenger substances in a small group of ring-shaped neurons in the ellipsoid body in the central brain of Drosophila.